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Citing amos version 351/7/2023 In contrast with comparative assemblers (which rely on a closely-related reference sequence), de novo assemblers have the ability to reconstruct organisms that have no sequenced close relatives or that contain novel gene content. The goal of sequence assembly is to take the shotgun-sequenced reads and recover the original whole genome. Whole-genome shotgun sequencing is a technique in which large pieces of DNA from genomes are randomly sheared into smaller fragments that are then cloned and sequenced. 1975) helped pave the way for the arrival of the first sequenced bacterial genome via whole-genome shotgun (WGS) sequencing in 1995 ( Fleischmann et al. Coulson on the rapid determination of DNA sequence ( Sanger et al. Over three decades ago, a highly influential work published by Fred Sanger and Alan R.
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